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While researchers traditionally focused on the anti-pathogenic response of MAIT cells, such as their direct cytotoxic activity and/or indirect antimicrobial activity in bacterial 190 , fungal 191 , and viral infections 192 , their protective role in epithelial barrier enforcement was only recently discovered in the context of the immune response to SARS-CoV-2 infections 193,194,195,196

The studies consistently reflected effects as tissue protection, inflammation control, and vascular stability

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Preclinical studies in animal models have yielded several noteworthy findings